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. 2024 Jul 5;25(13):7406. doi: 10.3390/ijms25137406

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© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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TUSC2 mRNA levels are decreased with age in the human blood and brain tissues. (A) A linear regression analysis shows progressive and significant age-dependent downregulation of the TUSC2 levels (TPM). Blue dots represent the TUSC2 levels in a single specimen, red arrows show statistically significant downward trends in TUSC2 expression in the groups of individuals ranging from 20 to 80 years old. The data were obtained from the Genotype-Tissue Expression (GTEx) database. All data are represented as the mean ± SD. n = 408 (68 samples per group). (B) Negative correlation observed between the age and TUSC2 expression levels in humans (the higher the age, the lower TUSC2 expression).