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Schematic diagram showing molecular mechanisms for leptin signaling in sweet-sensitive taste cells. Leptin binding to the leptin receptor (Ob-Rb) induces the activation of phosphoinositide 3-kinase (PI3K), leading to the production of phosphatidylinositol (3,4,5)-trisphosphate (PIP3) and phosphorylation of AKT. These signaling components might activate KATP channels to induce cell hyperpolarization, leading to the suppression of sweet responses (indicated by blue down arrow).
