Table 4.
Absolute and per cent change in lipid and lipoprotein parameters from baseline to Week 24
| Parameter | Evinacumab-naïve | Evinacumab-continue | Total |
|---|---|---|---|
| (n = 46) | n = 70 | n = 116 | |
| LDL-C, mmol/L, mean (SD) | |||
| Baseline | 7.0 (3.2) | 6.6 (4.7) | 6.8 (4.1) |
| Absolute change from baseline | −3.8 (2.7) | −3.2 (3.5) | −3.4 (3.2) |
| Per cent change from baseline | −47.8 (23.6) | −41.3 (43.7) | −43.6 (37.7) |
| Apolipoprotein B, g/L, mean (SD) | |||
| Baseline | 1.8 (0.7) | 1.7 (0.9) | 1.7 (0.8) |
| Absolute change from baseline | −0.8 (0.6) | −0.6 (0.6) | −0.7 (0.6) |
| Per cent change from baseline | −41.2 (20.4) | −34.6 (30.8) | −37.0 (27.6) |
| Non-HDL-C, mmol/L, mean (SD) | |||
| Baseline | 7.5 (3.1) | 7.2 (4.8) | 7.3 (4.2) |
| Absolute change from baseline | −4.1 (2.6) | −3.5 (3.6) | −3.7 (3.2) |
| Per cent change from baseline | −49.6 (19.3) | −44.2 (33.5) | −46.1 (29.2) |
| Total cholesterol, mmol/L, mean (SD) | |||
| Baseline | 8.6 (3.0) | 8.3 (4.7) | 8.4 (4.1) |
| Absolute change from baseline | −4.5 (2.7) | −3.8 (3.6) | −4.1 (3.3) |
| Per cent change from baseline | −47.5 (19.0) | −42.3 (26.7) | −44.2 (24.2) |
| Fasting triglycerides, mmol/L, median (Q1, Q3) | |||
| Baseline | 1.0 (0.7, 1.6) | 1.0 (0.6, 1.6) | 1.0 (0.7, 1.6) |
| Absolute change from baseline | −0.4 (−0.8, −0.2) | −0.6 (−0.9, −0.2) | −0.5 (−0.9, −0.2) |
| Per cent change from baseline | −50.8 (−58.3, −35.5) | −51.8 (−65.9, −36.8) | −51.8 (−62.7, −36.2) |
| Lipoprotein(a), nmol/L, median (Q1, Q3) | |||
| Baseline | 50.0 (23.0, 113.0) | 73.5 (32.0, 168.0) | 66.0 (28.0, 166.0) |
| Absolute change from baseline | −8.0 (−22.0, −1.0) | −9.0 (−29.0, 2.0) | −8.5 (25.0, 0.0) |
| Per cent change from baseline | −18.2 (−33.3, −4.4) | −12.4 (−31.8, 4.7) | −14.6 (31.8, 0.0) |
HDL-C, HDL cholesterol; LDL-C, LDL cholesterol; Q1, first quartile; Q3, third quartile; SD, standard deviation.