Figure 7.

Inducing new gastroduodenal lesions versus enhancing bleeding from pre-existing lesions. (A) Gastroduodenal erosions and ulcers induced by non-steroidal anti-inflammatory drugs. (B) Twelve-week cumulative incidences of gastroduodenal ulcers in osteoarthritis patients treated with low-dose aspirin, placebo, or ibuprofen. The figure was drawn with data from Laine et al., Gastroenterology 2004. (C) Gastrointestinal complications induced by non-steroidal anti-inflammatory drugs. (D) Estimated rates of upper gastrointestinal complications in men, according to age and the presence or absence of a history of such complications and regular treatment with low-dose aspirin. The vertical lines connecting each pair of black and red symbols depict the absolute excess of complications related to aspirin therapy. Reproduced from Patrono et al.,⁸ with permission from the Massachusetts Medical Society