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Stages of colorectal carcinogenesis and aspirin chemopreventive effects. The figure depicts the three clinical settings in which aspirin and other cyclooxygenase inhibitors have been or are being evaluated by randomized clinical trials. CR, colorectal; CRC, colorectal cancer; Lynch S., Lynch syndrome; RCT, randomized controlled trial. Reproduced from Patrono,7 with permission from the American Society for Pharmacology and Experimental Therapeutics
