A.a.	Aggregatibacter actinomycetemcomitans
AgP	aggressive periodontitis
AIAN	American Indian/Alaska Native
AMX	amoxicillin
APT	active periodontal therapy
ARGs	antibiotic-resistance genes
AT	antibiotics and mechanical treatment
BOP	bleeding on probing
CAL	clinical attachment level
C/MIP	Grade C Molar–Incisor Pattern Periodontitis
EMD	enamel matrix derivative
FDIS	full-mouth disinfection
GEE	generalized estimating equation
GI	gingival inflammation
GTR	guided tissue regeneration
HBO	hyperbaric oxygen
HS	healthy state
LPO	lactoperoxidase
MGEs	mobile genetic elements
MRGs	metal-resistance genes
MTZ	metronidazole
NB	negative binomial
NSPT	non-supportive periodontal therapy
OHI	hygiene education
PAD	photoactivated disinfection
PD	probing depth
PRISMA	Preferred Reporting Items for Systematic Reviews and Meta-Analyses
PROSPERO	The International Prospective Register of Systematic Reviews
PS	periodontitis state
RS	resolved state
SDD	sub-antibacterial dose doxycycline
SI	subgingival instrumentation
SRP	scaling and root planing
SRP + MM	scaling and root planing combined with minocycline hydrochloride microspheres
SURG	periodontal surgery
TET	locally administered tetracycline