Figure 2.

PPV-6 restores mitochondrial bioenergetic function impaired by Aβ25-35. Primary cortical cultures were exposed to Aβ25-35 (10 μM) with or without PPV-6 (200 μg/mL) for 24 h. One representative measurement of OCR is shown in (A); various indices for mitochondrial function, including basal respiration, maximal respiration, ATP production, and spare respiratory capacity are respectively shown in (B–E). Mean ± SEM from N = 4–5. Data were analyzed by means of a one-way ANOVA followed by a post-hoc Tukey test. * and # denote p < 0.05.