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. 2024 Jul 3;25(13):7316. doi: 10.3390/ijms25137316

Figure 7.

Figure 7

PPV-6 suppresses Aβ-induced SHH expression and blocks SHH-N-mediated neuronal CCR. (A) Primary cortical cultures were exposed to Aβ25-35 (10 μM) with or without PPV-6 (250 μg/mL) for 24 h before detection of SHH by means of western blotting. (B–D) Primary cortical cultures were exposed to SHH-N (300 ng/mL) with or without PPV-6 (250 μg/mL) for 24 h before detection of various cell cycle markers, including cyclin D1 (B), PCNA (C), and p-Histone H3 (D). Mean ± SEM from N = 4 in (A), N = 3 in (B), N = 3 in (C), and N = 5 in (D). Data were analyzed by means of a one-way ANOVA followed by a post-hoc Tukey test. *, #, and + all denote p < 0.05.