| Absolute | Relative |
| • Recent or current haemorrhage, trauma, or surgery | • Previous peptic ulceration |
| • Active peptic ulceration | • Warfarin |
| • Coagulation defects | • Liver disease |
| • Oesophageal varices | • Previous use of anistreplase or streptokinase within four years (use alternative agent) |
| • Coma | • Hypersensitivity (anistreplase, streptokinase) |
| • Recent or disabling cerebrovascular accident | • Heavy vaginal bleeding |
| • Hypertension | |
| • Aortic dissection |
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