Table 5.
The associations between IgG4 values (≤140, 141–280, and >280 mg/dL) and risks of different outcomes after propensity score matching (a matching ratio of 1:1).
| Non-Outcome | Outcome | Crude | Adjusted | Crude | Adjusted | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IgG4 Value (mg/dL) |
N | % | N | % | OR (95% CI) | p-Value | OR † (95% CI) | p-Value | OR (95% CI) | p-Value | OR † (95% CI) | p-Value | ||||
| Cancer | ||||||||||||||||
| ≤140 | 686 | 50.48 | 73 | 45.91 | 1.00 | (reference) | - | 1.00 | (reference) | - | ||||||
| 141–280 | 445 | 32.74 | 47 | 29.56 | 0.99 | (0.68, 1.46) | 0.970 | 1.09 | (0.74, 1.62) | 0.656 | 1.00 | (reference) | - | 1.00 | (reference) | - |
| >280 | 228 | 16.78 | 39 | 24.53 | 1.61 | (1.06, 2.44) * | 0.026 | 1.39 | (0.91, 2.13) | 0.128 | 1.62 | (1.03, 2.55) * | 0.037 | 1.20 | (0.75, 1.93) | 0.444 |
| Cholangitis | ||||||||||||||||
| ≤140 | 660 | 50.23 | 99 | 48.53 | 1.00 | (reference) | - | 1.00 | (reference) | - | ||||||
| 141–280 | 436 | 33.18 | 56 | 27.45 | 0.86 | (0.60, 1.21) | 0.384 | 0.93 | (0.65, 1.33) | 0.691 | 1.00 | (reference) | - | 1.00 | (reference) | - |
| >280 | 218 | 16.59 | 49 | 24.02 | 1.50 | (1.03, 2.18) * | 0.035 | 1.31 | (0.89, 1.93) | 0.168 | 1.75 | (1.15, 2.65) ** | 0.008 | 1.40 | (0.91, 2.16) | 0.122 |
| Cholangiocarcinoma | ||||||||||||||||
| ≤140 | 704 | 50.32 | 55 | 46.22 | 1.00 | (reference) | - | 1.00 | (reference) | - | ||||||
| 141–280 | 458 | 32.74 | 34 | 28.57 | 0.95 | (0.61, 1.48) | 0.821 | 1.04 | (0.66, 1.63) | 0.868 | 1.00 | (reference) | - | 1.00 | (reference) | - |
| >280 | 237 | 16.94 | 30 | 25.21 | 1.62 | (1.01, 2.59) * | 0.044 | 1.41 | (0.88, 2.28) | 0.157 | 1.71 | (1.02, 2.85) * | 0.042 | 1.31 | (0.77, 2.24) | 0.314 |
| Pancreatitis | ||||||||||||||||
| ≤140 | 595 | 49.17 | 164 | 53.25 | 1.00 | (reference) | - | 1.00 | (reference) | - | ||||||
| 141–280 | 415 | 34.3 | 77 | 25 | 0.67 | (0.50, 0.91) ** | 0.009 | 0.71 | (0.52, 0.96) * | 0.027 | 1.00 | (reference) | - | 1.00 | (reference) | - |
| >280 | 200 | 16.53 | 67 | 21.75 | 1.22 | (0.88, 1.68) | 0.241 | 1.09 | (0.78, 1.52) | 0.614 | 1.81 | (1.25, 2.61) ** | 0.002 | 1.54 | (1.05, 2.25) * | 0.027 |
| Pancreatic cancer | ||||||||||||||||
| ≤140 | 732 | 50.10 | 27 | 47.37 | 1.00 | (reference) | - | 1.00 | (reference) | - | ||||||
| 141–280 | 478 | 32.72 | 14 | 24.56 | 0.79 | (0.41, 1.53) | 0.491 | 0.87 | (0.45, 1.69) | 0.682 | 1.00 | (reference) | - | 1.00 | (reference) | - |
| >280 | 251 | 17.18 | 16 | 28.07 | 1.73 | (0.92, 3.26) | 0.091 | 1.49 | (0.78, 2.83) | 0.224 | 2.18 | (1.05, 4.53) * | 0.038 | 1.66 | (0.78, 3.52) | 0.187 |
| Ampullary cancer | ||||||||||||||||
| ≤140 | 750 | 50.00 | 9 | 50.00 | 1.00 | (reference) | - | 1.00 | (reference) | - | ||||||
| 141–280 | 485 | 32.33 | 7 | 38.89 | 1.20 | (0.44, 3.25) | 0.716 | 1.31 | (0.48, 3.56) | 0.598 | 1.00 | (reference) | - | 1.00 | (reference) | - |
| >280 | 265 | 17.67 | 2 | 11.11 | 0.63 | (0.14, 2.93) | 0.555 | 0.55 | (0.12, 2.57) | 0.444 | 0.52 | (0.11, 2.54) | 0.421 | 0.37 | (0.08, 1.82) | 0.221 |
Abbreviations: N, numbers of patients; OR, odds ratio; CI, confidence interval. † Adjusted OR: multivariable analysis including age and gender; * p-value < 0.05, ** p < 0.01.