Table 2.
Economic Burden and HRU in the First Year after Allo-HCT for Patients with or without Virus-Associated HC
| Characteristic | Patients with Virus-Associated HC (n = 759) | Patients without Virus-Associated HC (n = 12,604) | P Value |
|---|---|---|---|
| Total health care submitted charges (2019 USD) | |||
| Mean ± SD | 1,481,699 ± 1,508,451 | 795,221 ± 885,877 | <.0001 |
| Median [Q1; Q3] | 1,020,571 [538,421; 1,912,975] | 516,861 [224,627; 1,028,482] | |
| Total health care reimbursement (2019 USD) | |||
| Mean ± SD | 632,870 ± 640,815 | 340,469 ± 377,591 | <.0001 |
| Median [Q1; Q3] | 435,420 [229,588; 815,979] | 222,494 [97,746; 441,018] | |
| Overall LOS (index hospitalization and readmissions, d) | |||
| Mean ± SD | 76.8 ± 57.4 | 49.7 ± 47.4 | <.0001 |
| Median [Q1; Q3] | 62.0 [38.0; 98.0] | 35.0 [22.0; 61.0] | |
| Index hospitalization | |||
| Total inpatient reimbursement (2019 USD) | |||
| Mean ± SD | 174,881 ± 278,682 | 117,730 ± 175,660 | <.0001 |
| Median [Q1; Q3] | 89,571 [6,614; 207,154] | 67,410 [4,573; 155,405] | |
| LOS, d | |||
| Mean ± SD | 35.5 ± 31.5 | 27.6 ± 25.9 | <.0001 |
| Median [Q1; Q3] | 27.0 [19.0; 39.0] | 23.0 [16.0; 31.0] | |
| ICU stay during index hospitalization, n (%) | 223 (29.4) | 2942 (23.3) | .0001 |
| Time in ICU, d | |||
| Mean ± SD | 34.3 ± 26.6 | 28.2 ± 23.0 | .0009 |
| Median [Q1; Q3] | 28.0 [21.0; 39.0] | 25.0 [17.0; 33.0] | |
| Readmissions after index hospitalization, n (%) | 627 (82.6) | 7507 (59.6) | <.0001 |
| Total inpatient reimbursement (2019 USD) | |||
| Mean ± SD | 207,149 ± 314,649 | 109,686 ± 174,644 | <.0001 |
| Median [Q1; Q3] | 95,758 [267; 2,075,607] | 39,986 [48; 1,000,873] | |
| LOS after index, d | |||
| Mean ± SD | 50.0 ± 49.3 | 37.1 ± 44.0 | <.0001 |
| Median [Q1; Q3] | 35.0 [17.0; 68.0] | 21.0 [9.0; 49.0] | |
| ICU stays after index hospitalization, n (%) | 332 (43.7) | 3480 (27.6) | <.0001 |
| Time in ICU, d | |||
| Mean ± SD | 25.8 ± 31.7 | 18.5 ± 24.9 | <.0001 |
| Median [Q1; Q3] | 13.5 [4.0; 34.5] | 9.0 [4.0; 23.0] | |
| Readmission rate (per person year) (95% CI) | 3.47 (3.34–3.62) | 1.92 (1.90–1.95) | <.0001 |
| Outpatient visits, n (%) | 752 (99.1) | 12,040 (95.5) | <.0001 |
| Total outpatient reimbursement (2019 USD) | |||
| Mean ± SD | 88,436 ± 71,593 | 59,531 ± 55,349 | <.0001 |
| Median [Q1; Q3] | 70,638 [34,981; 124,388] | 45,350 [20,096; 82,718] | |
| Number of outpatient visits | |||
| Mean ± SD | 42.6 ± 30.2 | 33.7 ± 25.5 | <.0001 |
| Median [Q1; Q3] | 39.0 [19.0; 59.0] | 29.0 [14.0; 47.0] | |
| ER visits, n (%) | 437 (57.6) | 5717 (45.4) | <.0001 |
| Number of ER visits | |||
| Mean ± SD | 3.2 ± 5.7 | 2.5 ± 2.3 | .0058 |
| Median [Q1; Q3] | 2.0 [1.0; 4.0] | 2.0 [1.0; 3.0] | |
| Physician office visits, n (%) | 417 (54.9) | 6843 (54.3) | .7276 |
| Number of physician office visits | |||
| Mean ± SD | 16.0 ± 19.0 | 14.7 ± 16.9 | .1718 |
| Median [Q1; Q3] | 9.0 [2.0; 24.0] | 7.0 [2.0; 23.0] | |
Q1 indicates first quartile; Q3, third quartile; ER, emergency room.