Figure 9.

(A) Representation of the Cryo-EM structure of Kv7.2 in complex with retigabine (PDB ID: 7CR2). Kv7.2 is represented by cartoons and surface while retigabine is represented by spheres inside the PD binding site. Cartoons are colored as follows: PD of one subunit is colored in blue, while the VSD of the same subunit is colored in yellow. The other subunits are represented in gray. (B) Experimental bound conformation of retigabine (pink sticks). Residues of the pocket are represented in light blue sticks, and include Trp236, Ser303, and Lys299 involved in polar interactions (represented as yellow dashed lines) in the pocket comprised between S5 and S6 helices (PD) [11].