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. 2024 Jul 4;29(13):3186. doi: 10.3390/molecules29133186

Table 1.

Assessment of the antiproliferative activity (IC50) of the target compounds 4a–r against the HepG-2, HCT-116, MCF-7, and WI-38 cell lines.

graphic file with name molecules-29-03186-i001.jpg
Comp. No. R R1 R2 IC50 (µM)
HePG-2 HCT-116 MCF-7 WI-38
4a H H H 12.88 ± 0.9 9.94 ± 0.8 5.91 ± 0.3 66.22 ± 3.5
4b H CH3 H 48.25 ± 2.5 61.78 ± 3.3 46.53 ± 2.6 80.95 ± 4.2
4c H OCH3 H 42.22 ± 2.6 65.48 ± 3.5 54.46 ± 2.9 91.31 ± 4.6
4d H Cl H 30.20 ± 2.3 39.69 ± 2.3 33.64 ± 2.0 89.09 ± 4.3
4e H F H 63.39 ± 3.4 82.45 ± 4.2 67.10 ± 3.4 >100
4f H CF3 Cl 5.05 ± 0.3 6.21 ± 0.4 2.74 ± 0.1 41.24 ± 2.4
4g CH3 H H 22.93 ± 1.8 19.60 ± 1.3 16.46 ± 1.2 79.42 ± 4.0
4h CH3 CH3 H 37.36 ± 2.5 56.22 ± 3.0 40.62 ± 2.3 87.80 ± 4.4
4i CH3 OCH3 H 53.10 ± 2.7 76.69 ± 3.9 59.53 ± 3.1 45.45 ± 2.6
4j CH3 Cl H 78.13 ± 3.9 >100 84.19 ± 4.2 >100
4k CH3 F H 64.23 ± 3.7 92.02 ± 4.6 69.52 ± 3.5 58.45 ± 3.2
4l CH3 CF3 Cl 15.36 ± 1.2 13.54 ± 1.0 9.46 ± 0.6 47.54 ± 2.7
4m Cl H H 29.84 ± 2.0 34.39 ± 2.1 28.93 ± 1.9 74.45 ± 3.8
4n Cl CH3 H 32.84 ± 2.4 44.84 ± 2.5 36.72 ± 2.1 >100
4o Cl OCH3 H 35.03 ± 2.4 51.63 ± 2.8 43.45 ± 2.4 26.36 ± 1.8
4p Cl Cl H 57.03 ± 3.1 71.29 ± 3.7 62.57 ± 3.2 94.11 ± 4.9
4q Cl F H 27.38 ± 2.2 25.39 ± 1.8 21.72 ± 1.5 49.73 ± 2.9
4r Cl CF3 Cl 8.10 ± 0.6 7.81 ± 0.6 3.85 ± 0.2 38.77 ± 2.2
SOR 9.18 ± 0.6 5.47 ± 0.3 7.26 ± 0.3 10.65 ± 0.8