Table 4.

Binding score of the compounds under investigation and reference inhibitors.

Compound	VEGFR-2 Binding Energy (kcal/mol) RMSD = 0.5	BRAF Binding Energy (kcal/mol) RMSD = 0.8
4a	−9.4	−8.5
4f	−10.4	−9.3
4r	−8.9	−8.2
Sorafenib	−11.6	−10.2
Dabrafenib	---	−9.7