Table 1.

Experimental matrix and results in the BBD: X₁—temperature; X₂—solvent ratio; X₃—extraction cycles. Data are given as the mean values in µg/g of plant material ± SD.

Run Order	Independent Variables			Response Variables
	X1	X2	X3	FAd	p-CA	3-gluK	EA	Tiliroside	Yield (%)
1	0	0	0	74.67 ± 1.70	83.10 ± 2.22	134.80 ± 2.71	257.44 ± 1.20	1757.4 ± 32.1	5.41 ± 0.07
2	−1	0	1	62.49 ± 0.75	72.33 ± 1.13	101.88 ± 2.88	280.55 ± 1.52	1196.0 ± 45.6	5.40 ± 0.02
3	1	0	−1	65.70 ± 0.69	77.57 ± 1.50	157.52 ± 3.60	312.61 ± 2.38	1948.1 ± 8.8	5.58 ± 0.05
4	−1	0	−1	55.28 ± 1.68	69.49 ± 1.16	102.84 ± 0.29	260.21 ± 1.75	1085.3 ± 24.6	5.31 ± 0.10
5	0	1	1	50.44 ± 0.79	59.47 ± 0.82	66.67 ± 1.25	41.28 ± 2.26	252.32 ± 4.87	6.22 ± 0.13
6	0	0	0	72.84 ± 1.41	75.65 ± 4.94	128.50 ± 1.69	267.20 ± 3.46	1766.1 ± 14.2	5.48 ± 0.02
7	1	0	1	62.88 ± 2.32	78.84 ± 0.98	151.83 ± 6.94	308.69 ± 3.32	2064.7 ± 36.3	5.65 ± 0.09
8	0	1	−1	51.50 ± 1.69	44.36 ± 1.49	46.35 ± 3.42	34.29 ± 1.26	205.75 ± 17.3	5.71 ± 0.06
9	0	−1	1	64.22 ± 0.51	81.03 ± 0.44	143.84 ± 1.56	381.02 ± 11.7	1840.5 ± 5.4	5.10 ± 0.07
10	0	−1	−1	59.76 ± 0.20	75.81 ± 1.37	121.50 ± 0.14	293.37 ± 2.76	1775.9 ± 32.3	4.85 ± 0.18
11	0	0	0	70.85 ± 2.39	80.09 ± 1.13	122.82 ± 4.01	261.01 ± 1.62	1805.3 ± 14.4	5.53 ± 0.04
12	1	−1	0	65.45 ± 1.08	83.43 ± 1.24	143.37 ± 1.64	367.91 ± 3.20	2230.1 ± 19.3	5.25 ± 0.04
13	1	1	0	48.93 ± 6.07	65.57 ± 1.32	86.48 ± 3.40	42.36 ± 1.26	264.35 ± 6.91	6.10 ± 0.16
14	−1	1	0	43.79 ± 1.81	41.48 ± 1.53	36.64 ± 3.69	31.13 ± 1.16	145.8 ± 5.29	5.75 ± 0.11
15	−1	−1	0	63.53 ± 2.63	76.02 ± 2.49	109.01 ± 11.9	307.05 ± 17.8	1353.4 ± 19.4	4.67 ± 0.13

FAd—ferulic acid derivative; pCA—p-coumaric acid; 3-gluK—kaempferol 3-glucoside; EA—ellagic acid.