Table 1.
Association of missense variants in the GIPR gene with body mass index
| Variant | Pos_build38 | EA/NEA | Freq. EA % | Model | P | Effect (95% CI) | P het |
|---|---|---|---|---|---|---|---|
| rs1800437 | 19:45678134 | C/G | 20.9 | A | 4.8E-43 | −0.033 (−0.038 to −0.028) | .07 |
| R | 5.6E-19 | −0.057 (−0.070 to −0.044) | .23 | ||||
| rs139215588 | 19:45674762 | A/G | 0.12 | A | 7.7E-06 | −0.117 (−0.168 to −0.066) | .15 |
| R | NA | NA | NA | ||||
| rs143430880 | 19:45677718 | G/A | 0.12 | A | 6.3E-07 | −0.123 (−0.171 to −0.075) | .09 |
| R | NA | NA | NA |
The 3 SNVs, rs1800437[C/G] (p.Glu354Gln), rs139215588[A/G] (p.Arg190Gln), and rs143430880[G/A] (p.Glu288Gly), were evaluated for association with body mass index in 629 233 individuals from the 4 populations used in the fracture study: Iceland, United States, and Denmark. The association model, P values, and effect in SD with 95% CIs are shown. Phet is the heterogeneity P value. A is additive model and R is recessive model.
Abbreviations: NA, not available; SNV, single-nucleotide variation.