Table 2.
Association of the 3 body mass index missense variants in the GIPR gene with fractures
| rs1800437[C]—21.4% | rs139215588[A]—0.12% | rs143430880[G] −0.13% | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Group | Fracture | N cases/N controls | Model | P | OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) |
| Postmenopausal | Nonvertebral | 105 739/350 006 | A | .001 | 0.98 (0.96-0.98) | .41 | 0.99 (0.98-1.01) | .15 | 1.12 (0.96-1.30) |
| R | .12 | 0.97 (0.93-1.01) | NA | NA | NA | NA | |||
| Osteoporotic | 52 277/350 005 | A | 1.8E-4 | 0.97 (0.95-0.98) | .60 | 1.11 (0.75-1.63) | .02 | 1.32 (1.05-1.65) | |
| R | .12 | 0.96 (0.91-1.01) | NA | NA | NA | NA | |||
| Hip | 21 046/340 503 | A | .03 | 0.95 (0.92-1.00) | .57 | 1.14 (0.73-1.80) | .37 | 1.27 (0.75-2.14) | |
| R | .40 | 0.97 (0.90-1.04) | NA | NA | NA | NA | |||
| Vertebral | 7942/340 548 | A | .21 | 0.98 (0.96-1.01) | .15 | 0.89 (0.75-1.04) | .06 | 1.42 (0.99-2.01) | |
| R | .34 | 0.95 (0.84-1.06) | NA | NA | NA | NA | |||
| All | Any type | 352 343/906 092 | A | .11 | 0.99 (0.99-1.00) | .24 | 1.06 (0.96-1.18) | .20 | 1.06 (0.97-1.16) |
| R | .08 | 0.98 (0.96-1.00) | NA | NA | NA | NA | |||
| Hip | 34 127/896 691 | A | .20 | 0.99 (0.97-1.01) | .97 | 0.99 (0.72-1.38) | .09 | 1.24 (0.97-1.60) | |
| R | .43 | 0.98 (0.92-1.04) | NA | NA | NA | NA | |||
| Forearm/wrist | 79 986/851 397 | A | .61 | 1.00 (0.98-1.01) | .41 | 1.08 (0.90-1.31) | .20 | 1.11 (0.95-1.30) | |
| R | .07 | 0.97 (0.93-1.00) | NA | NA | NA | NA | |||
| Vertebral | 18 473/869 228 | A | .05 | 0.97 (0.95-1.00) | .03 | 1.44 (1.04-1.99) | .65 | 1.08 (0.76-1.54) | |
| R | .41 | 0.97 (0.90-1.04) | NA | NA | NA | NA | |||
The 3 SNVs, rs1800437[C/G] (p.Glu354Gln), rs139215588[A/G] (p.Arg190Gln), and rs143430880[G/A] (p.Glu288Gly), were evaluated for association with fractures in postmenopausal women, and in all participants, irrespective of sex and age. Shown are the type of fracture, number (N) of cases and controls, the association model, P values, and ORs with 95% CIs. A is additive model and R is recessive model.
Abbreviations: NA, not available; OR, odds ratio; SNV, single-nucleotide variation.