Table 3.
Association of the 3 body mass index missense variants in the GIPR gene with bone mineral density
| BMD | N individuals | Model | rs1800437[C]—21.4% | rs139215588[A]—0.12% | rs143430880[G] −0.13% | |||
|---|---|---|---|---|---|---|---|---|
| P | Effect (95% CI) | P | Effect (95% CI) | P | Effect (95% CI) | |||
| Lumbar spine | 102 184 | A | .0001.4E-4 | 0.022 (0.011 to 0.033) | .38 | −0.056 (−0.179 to 0.068) | .27 | −0.092 (−0.253 to 0.070) |
| 74 539 | R | .07 | 0.035 (−0.003 to 0.072) | NA | NA | NA | NA | |
| Femoral neck | 101 082 | A | .39 | 0.005 (−0.006 to 0.015) | .66 | −0.027 (−0.148 to 0.094) | .41 | −0.067 (−0.227 to 0.093) |
| 75 650 | R | .44 | −0.015 (−0.052 to 0.023) | NA | NA | NA | NA | |
| Total body | 102 021 | A | .04 | 0.012 (0.000 to 0.023) | .35 | 0.065 (−0.072 to 0.202) | .23 | −0.097 (−0.256 to 0.061) |
| 55 693 | R | .84 | 0.004 (−0.038 to 0.046) | NA | NA | NA | NA | |
| eBMD | 398 823 | A | .19 | −0.004 (−0.010 to 0.002) | .20 | −0.041 (−0.104 to 0.022) | .02 | −0.066 (−0.121 to −0.011) |
| 398 823 | R | .04 | −0.016 (−0.031 to −0.001) | NA | NA | NA | NA | |
The 3 SNVs, rs1800437[C/G] (p.Glu354Gln), rs139215588[A/G] (p.Arg190Gln), and rs143430880[G/A] (p.Glu288Gly), were evaluated for association with BMD at different skeletal sites, with number of individuals (N) shown, the association model, P value, effect in SDs, and 95% CI.
Abbreviations: BMD, bone mineral density; eBMD, BMD estimated from heel ultrasound; NA, not available; SNV, single-nucleotide variation.