Figure 9.

Dio3 deficiency influences gene expression in the Dlk1-Dio3 imprinted domain.

(a-d) Postnatal day 4 (P4) gene expression in hypothalamus (a), cerebrocortex (b), testis (c) and Liver (d). (Note that Dio3 -/- mice carry a mutation that completely inactivates the DIO3 protein, but they still express a full Dio3 mRNA). Data represent the mean ± SEM of mouse samples representing at least three different litters. ***, ** and * indicate p < 0.001, p < 0.01 and p < 0.05, respectively, Dio3 +/+ vs. Dio3 -/-, as determined by the Student’s t-test.