Figure 5.

Inhibitory effects of defatted rice bran (DFRB) and husk (H) extracts of Oryza sativa cv. Sang 5 CMU on (a) intracellular melanin content and (b) tyrosinase activity in human melanoma cells after exposure to 100 μM 3-isobutyl-1-methylxanthine (IBMX). (c) Cell pellets after treatment with each sample for 48 h. Arbutin (Ar) was used as a positive control. Experiments were performed in triplicate. Bars represent mean ± standard deviation. Different superscript letters (a and b) were significantly different at p < 0.05, while the same letter showed no significant difference according to a one-way ANOVA test, followed by LSD post hoc test.