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[Preprint]. 2024 Jul 4:2024.07.02.601712. [Version 1] doi: 10.1101/2024.07.02.601712

Figure 4: Oscillating and non-oscillating PSM cells exhibit distinct traction force profiles across substrate rigidities.

Figure 4:

(A-B) Her1-Venus intensity and traction force heat maps of oscillating (A) and non-oscillating (B) isolated cells on 0.6 kPa micropost arrays. Oscillating cells maintain lower traction forces, while non-oscillating cells progressively increase traction force. (C) Her1 intensity and force profiles over time for the oscillating (red) and non-oscillating (blue) cells. (D) Quantitative analysis of total force per cell area for oscillating (N = 2) and non-oscillating (N = 5) isolated PSM cells cultured on 0.6 kPa micropost arrays. Oscillating cells maintain lower total force per cell area, while non-oscillating cells show a wide range of total force per cell area over time. (E) Quantitative analysis of total force per cell area for oscillating (N = 2) and non-oscillating (N = 5) isolated PSM cells cultured on 2.4 kPa micropost arrays. Similar to the 0.6 kPa condition, oscillating cells maintain lower total force per cell area compared to non-oscillating cells, which exhibit a wide range of total force per cell area over time.