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Differences in DNA methylation-based immune cell type proportions estimated using the IDOL reference on matched samples assessed on EPICv1 and EPICv2 in VHAS, CLHNS, and CALERIE. Statistical significance was defined as Bonferroni adjusted p-value <0.05. ** denotes Bonferroni p <0.05, *** denotes Bonferroni p <0.001, “ns” denotes “not significant”, and “d” denotes effect size measured using Cohen’s d. A positive Cohen’s d indicates higher estimates in EPICv2 compared to EPICv1.
