Figure 3. Memantine inhibition of GluA2 (E) /γ2.

(A) Representative whole-cell recordings in response to 10 mM glutamate alone (black) or in the presence of 500µM of memantine (pink). (B) The dose dependence of memantine inhibition on GluA2 (E) /γ2 at −60 (•) and −100 (•) mV, with IC₅₀ 25 ± 2 µM and 5.7 ± 1 µM, respectively. Each dot represents data from a different cell. (C) Single-channel currents recorded from GluA2 (E) /γ2 during continuous application of 10 mM glutamate alone (blue) and in the presence 500 µM of memantine (pink). Openings are shown as downward deflections. (D) Amplitude histogram from the single channel recordings showing conductance (n = 5).