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[Preprint]. 2024 Jul 4:2024.07.02.601784. [Version 1] doi: 10.1101/2024.07.02.601784

Figure 4. mEPSCs inhibition by Memantine (MEM).

Figure 4.

(A) Representative spontaneous mEPSCs in native neurons, in control (blue) and (B) in the presence of 10 µM of memantine (pink) (p = 0.7). (C) mEPSC amplitude and frequency were measured from individual neurons. Paired data from each experiment are connected by a line. (D) Bar graphs of the average values of the normalized mEPSC amplitude and frequency, in control (blue) and in the presence of 10 µM of memantine (pink) (n = 10). (E) Representative spontaneous mEPSCs in GluA2 (Q)/γ2 neurons, in control (blue) and (J) in the presence of 10 µM of memantine (pink) (p = 0.02). (G) mEPSC amplitude and frequency from individual neurons. (H) Bar graphs of the average values of amplitude and frequency (n = 10). (I) Representative spontaneous mEPSCs in GluA2 (E)/γ2 neurons, in control (blue) and (J) in the presence of 10 µM of memantine (pink) (p = 0.01). (K) mEPSC amplitude and frequency from individual neurons. (L) Bar graphs of the average values of amplitude and frequency (n = 66).