Figure 6. A CD200-targeting switch receptor allows TTCR-MCC1 cells control HLA-low MCC cells in mice.
a CD200 expression in MCC. A representative image from Pt 1 is shown. b Design of TCRMCC1/CD200R-CD28/CD8αβ construct. c In vivo tumor control by T cells with the indicated transgene. 4 mice per arm. d Frequency of human CD4 and CD8 T cells in digested tumor single cell suspension. e HLA expression on tumor (huCD45- CD56+) cells measured by flow cytometry.