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[Preprint]. 2024 Jul 5:2024.07.02.24309792. [Version 1] doi: 10.1101/2024.07.02.24309792

Table 1.

Clinical characteristics of patients treated on NCT #04663347.

Patient N. Histology Setting Prior therapies Best response Last follow-up
Treatment Response Status
1 DLBCL, non-GCB ND CR Completed CR A
2 DLBCL, non-GCB ND CR Completed CR A
3 DLBCL (tFL), non-GCB ND CR Completed CR A
4 DLBCL, non-GCB ND CR Completed CR A
5 DLBCL, GCB ND CR Completed CR A
6 DLBCL (tFL), GCB ND CR Completed CR A
7 DLBCL ND CR Completed CR A
8 DLBCL RR R-EPOCH; R-ICE; CAR-T PR Completed PD D
9 DLBCL, non-GCB RR R-CHOP/R-ICE; R-DHAX; CAR-T PR Completed PD D
10 FL, G1–2 ND CR Completed CR A
11 FL, G1–2 ND CR Completed CR A
12 FL, G3A ND CR Ongoing CR A
13 FL, G1–2 RR R-CHOP CR Completed CR A
14 FL, G1–2 RR R-CHOP CR Ongoing CR A
15 FL, G1–2 RR R-CHOP; R-len CR Ongoing CR A
16 FL, G1–2 RR BR CR Completed PD A
17 FL, G3A RR R-CHOP CR Completed CR A
18 FL, G3A RR O-CVP; O-CEOP; RT CR Completed CR A
19 FL, G1–2 (prior DLBCL) RR R-CHP-polatuzumab (for DLBCL) CR Completed CR A
20 FL, G1–2 (prior DLBCL) RR R-EPOCH, R-GemOx, CAR-T, R-DHAX, O-len, other* PD Completed PD D
21 FL, G1–2 RR O-CHOP CR Ongoing CR A
22 FL, G1–2 RR O-CHOP, BR-HDT-ASCS CR Ongoing CR A

Study arms: 1, epcor-R-CHOP; 5, epcor-GemOx; 6 adn 2b, epcor_R-len.

*

pembrolizumab-entinostat, zanubrutinib-zandelisib both as part of a clinical trial. Abbreviations: DLBCL, diffuse large B-cell lymphoma; GCB, germinal center B; (t)FL, (transformed) follicular lymphoma; G, grade; ND, newly diagnosed; RR, relapsed or refractory; R, rituximab; EPOCH, etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin; CAR-T, chimeric antigen receptor cell therapy; CHOP, rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone; len, lenalidomide DHAX, dexamethasone, cytarabine, oxaliplatin, B, bendamustine; CVP, cyclophosphamide, vincristine, prednisone; GemOx, gemcitabine, oxaliplatin; HDT-ASCS, high-dose therapy adn autologous stem cell support; epcor, epcoritamab; CR, complete response; PR, partial response; PD, progressive disease; A, alive, D, dead.