Table 1.
Patient N. | Histology | Setting | Prior therapies | Best response | Last follow-up | ||
---|---|---|---|---|---|---|---|
Treatment | Response | Status | |||||
1 | DLBCL, non-GCB | ND | CR | Completed | CR | A | |
2 | DLBCL, non-GCB | ND | CR | Completed | CR | A | |
3 | DLBCL (tFL), non-GCB | ND | CR | Completed | CR | A | |
4 | DLBCL, non-GCB | ND | CR | Completed | CR | A | |
5 | DLBCL, GCB | ND | CR | Completed | CR | A | |
6 | DLBCL (tFL), GCB | ND | CR | Completed | CR | A | |
7 | DLBCL | ND | CR | Completed | CR | A | |
8 | DLBCL | RR | R-EPOCH; R-ICE; CAR-T | PR | Completed | PD | D |
9 | DLBCL, non-GCB | RR | R-CHOP/R-ICE; R-DHAX; CAR-T | PR | Completed | PD | D |
10 | FL, G1–2 | ND | CR | Completed | CR | A | |
11 | FL, G1–2 | ND | CR | Completed | CR | A | |
12 | FL, G3A | ND | CR | Ongoing | CR | A | |
13 | FL, G1–2 | RR | R-CHOP | CR | Completed | CR | A |
14 | FL, G1–2 | RR | R-CHOP | CR | Ongoing | CR | A |
15 | FL, G1–2 | RR | R-CHOP; R-len | CR | Ongoing | CR | A |
16 | FL, G1–2 | RR | BR | CR | Completed | PD | A |
17 | FL, G3A | RR | R-CHOP | CR | Completed | CR | A |
18 | FL, G3A | RR | O-CVP; O-CEOP; RT | CR | Completed | CR | A |
19 | FL, G1–2 (prior DLBCL) | RR | R-CHP-polatuzumab (for DLBCL) | CR | Completed | CR | A |
20 | FL, G1–2 (prior DLBCL) | RR | R-EPOCH, R-GemOx, CAR-T, R-DHAX, O-len, other* | PD | Completed | PD | D |
21 | FL, G1–2 | RR | O-CHOP | CR | Ongoing | CR | A |
22 | FL, G1–2 | RR | O-CHOP, BR-HDT-ASCS | CR | Ongoing | CR | A |
Study arms: 1, epcor-R-CHOP; 5, epcor-GemOx; 6 adn 2b, epcor_R-len.
pembrolizumab-entinostat, zanubrutinib-zandelisib both as part of a clinical trial. Abbreviations: DLBCL, diffuse large B-cell lymphoma; GCB, germinal center B; (t)FL, (transformed) follicular lymphoma; G, grade; ND, newly diagnosed; RR, relapsed or refractory; R, rituximab; EPOCH, etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin; CAR-T, chimeric antigen receptor cell therapy; CHOP, rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone; len, lenalidomide DHAX, dexamethasone, cytarabine, oxaliplatin, B, bendamustine; CVP, cyclophosphamide, vincristine, prednisone; GemOx, gemcitabine, oxaliplatin; HDT-ASCS, high-dose therapy adn autologous stem cell support; epcor, epcoritamab; CR, complete response; PR, partial response; PD, progressive disease; A, alive, D, dead.