Figure 6. PV cells show more overlap in biological processes enriched for rhythmic transcripts between sexes in dark phase.

(A) Radar plot showing the peak time of rhythmic transcripts (p<0.05) in PV cells from both males and females. Data is presented as the proportion of total rhythmic transcripts peaking within 2-hour bins across a 24-hour period (ZT). Rhythmic transcripts in females form two groups, one peaking in the light phase and one peaking in the dark phase. In males, rhythmic transcripts form a small group that peaks in the light phase, but are fairly evenly distributed in the dark phase. (B) Phase concordance plot showing the peak time (ZT) of individual shared rhythmic transcripts in females (X axis) and males (Y axis). Shared rhythmic transcripts largely peak at similar times between sexes. (C)&(D) The top 10 pathways (IPA) enriched for rhythmic transcripts in males and females separated by the phase in which they peak. Transcripts that peak during the light phase (ZT0–12) are plotted in (C) while transcripts that peak during the dark phase (ZT12–24) are plotted in (D). There is more overlap in pathways enriched for rhythmic transcripts in the dark phase. ZT=Zeitgeber time, PV=parvalbumin cells, IPA=Ingenuity Pathway Analysis