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. 2024 Jul 12;14:16097. doi: 10.1038/s41598-024-67052-3

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Mediation analyses of TyG-BMI index and cognition/brain structure. (A–C) Mediation analyses of TyG-BMI index and cognition as well as brain structure with biomarkers as mediators. (D–F) Mediation analyses of TyG-BMI index and cognition with brain structure as mediators. TyG-BMI index, triglyceride glucose-body mass index; Aβ42, Amyloid-42; pTau, phosphorylated-tau; Tau, total-tau; MMSE, mini-mental state examination; ADAS, Alzheimer’s Disease Assessment Scale-Cognitive Subscale Question; MEM, memory function.