Table 2.
Association of TyG-BMI index and pathology, cognition as well as brain structure.
| Characteristic | Tertile1 | Tertile2 | Tertile3 | |||
|---|---|---|---|---|---|---|
| OR (95%CI) | P | OR (95%CI) | P | OR (95%CI) | P | |
| AD pathology | ||||||
| Aβ42 | Reference | 1.217 (1.049, 1.413) | 0.001 | 1.353 (1.161, 1.576) | 1.19E−04 | |
| Tau | Reference | 0.971 (0.831, 1.135) | 0.711 | 0.785 (0.669, 0.922) | 0.003 | |
| pTau | Reference | 0.950 (0.815, 1.109) | 0.519 | 0.767 (0.654, 0.899) | 0.001 | |
| Tau/Aβ42 | Reference | 0.871 (0.754, 1.006) | 0.061 | 0.731 (0.614, 0.827) | 9.06E−06 | |
| pTau/Aβ42 | Reference | 0.878 (0.759, 1.106) | 0.081 | 0.717 (0.617, 0.833) | 1.56E−05 | |
| pTau/Tau | Reference | 0.847 (0.726, 0.988) | 0.035 | 0.727 (0.620, 0.852) | 9.32E−05 | |
| Cognition | ||||||
| MMSE | Reference | 0.951 (0.817, 1.107) | 0.516 | 1.157 (0.990, 1.353) | 0.067 | |
| ADAS | Reference | 0.865 (0.745, 1.004) | 0.057 | 0.751 (0.645, 0.876) | 2.75E−05 | |
| MEM | Reference | 1.118 (0.976, 1.282) | 0.109 | 1.300 (1.129, 1.496) | 2.78E−04 | |
| EF | Reference | 1.167 (1.000, 1.362) | 0.051 | 1.238 (1.055, 1.452) | 0.009 | |
| Brain structure | ||||||
| Hippocampus | Reference | 1.064 (0.903, 1.255) | 0.457 | 1.360 (1.148, 1.612) | 4.10E−04 | |
| Entorhinal | Reference | 1.084 (0.920, 1.276) | 0.335 | 1.342 (1.131, 1.592) | 7.76E−04 | |
| MidTemp | Reference | 1.130 (0.970, 1.318) | 0.117 | 1.227 (1.045, 1.439) | 0.013 | |
TyG-BMI index, triglyceride glucose-body mass index; AD, Alzheimer’s Disease; MMSE, mini-mental state examination, ADAS, Alzheimer’s Disease Assessment Scale-Cognitive Subscale Question; EF, executive function; MEM, memory function. Aβ42, Amyloid-42; pTau, phosphorylated-tau; Tau, total-tau.
All factors adjusted for sex, age, ethnicity, Apolipoprotein E4, cognitive dignosis, diabetes, education, smoking, drinking, hypertension and cardiovascular disease, brain structure additionally adjusted for intracerebral volume.