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. 2024 Jul 12;11:768. doi: 10.1038/s41597-024-03485-9

Table 5.

Knight-ADRC participants with high-throughput data available distributed by data type and tissue of origin.

Genomics Proteomics Metabolomics & Lipidomics Methylation Transcriptomics
Array-based WES WGS Plasma CSF Brain Plasma CSF Brain Brain Blood Brain sRNA Plasma sRNA Plasma cfRNA Blood Brain
AD 2,085 578 928 1,266 295 320 1,285 286 342 344 15 283 94 134 312 371
ADAD 20 5 16 10 4 6 9 4 7 7 . 4 . . 2 7
ADRD 531 85 165 349 109 32 359 69 33 34 . 3 17 21 359 38
Control 1,999 382 907 1,432 642 27 1,431 575 29 29 5 34 29 110 801 37
DLB 64 10 20 35 4 9 37 4 11 11 . 3 13 16 2 14
FTD 144 9 38 45 10 18 48 10 19 19 . 3 11 12 9 23
Total 4,843 1,069 2,074 3,137 1,064 412 3,169 948 441 444 20 330 164 293 1,485 490

WES = Whole Exome Sequencing; WGS = Whole Genome Sequencing; CSF = CerebroSpinal Fluid; sRNA = Small RNA; cfRNA = Cell-Free RNA; AD = Alzheimer Disease; ADAD = Autosomal Dominant Alzheimer Disease; ADRD = Alzheimer Disease Related Dementia; DLB = Lewy Body Dementia; FTD = FrontoTemporal Dementia

This table does not include longitudinal sample; for several individuals, more than one time-point (or brain region) is available.