Table 1.

Model parameters.

Notation	Description
pcrit	Critical protein threshold, number of protein molecules needed to achieve 10−9 M concentration in nucleus
Tp	Delay associated with protein production (min)
Tm	Delay associated with mRNA production (min), sum of:
Ttx	Transcription delay (min)
Tin	Intron splicing delay (min)
Texp	mRNA export delay (min)
a	Rate of protein synthesis (protein/mRNA/min)
k	Rate of mRNA synthesis, no repression (mRNA/min/cell)
b	Rate constant of protein degradation (min−1), equal to ln(2)/hp
hp	Protein half-life (min)
c	Rate constant of mRNA degradation (min−1), equal to ln(2)/hm
hm	mRNA half-life (min)