3. Additional data on efficacy and safety outcomes in studies with antifibrinolytic agents in people with haemophilia undergoing dental extractions (Walsh 1971; Forbes 1972).

Outcome	Walsh 1971		Forbes 1972
	EACA n = 15	Placebo n = 16	Tranexamic acid n = 16	Placebo n = 16
Blood loss per participant, mean (range), ml	n.e.	n.e.	61.2 (1 ‐ 749)	84.1 (4 ‐ 323)
Reduction in Hb levels	3.9/3.7%*	6.3/6.3 %*	0.3^	1.4^
Post‐operative replacement treatment administration, number of participants (%)	1 (6.7)	9 (56.3)	2 (12.5)	11 (68.8)
Serious side effects, number of participants (%)	1 (6.7)	0 (0)	0 (0)	0 (0)
Any side effect, number of participants (%)	12 (80)	8 (50)	0 (0)	0 (0)

*percentage reduction from the baseline, values reported at the 2 participating centres; ^reduction in g/100 ml

n: number
 n.e.: not evaluated