7. Bolus infusion vs continuous infusion of rFVIIa in people with haemophilia and inhibitors undergoing surgery ‐ Total dose, duration of treatment, need for additional/alternative therapy and safety (Pruthi 2007).

Outcome measure	Bolus infusion n = 11	Continuous infusion n = 12
Median duration of therapy, days	10	9
Treatment for > 10 days, number of participants	5	6
Mean total dose of rFVIIa, mg	237.5	292.2
Total number of additional bolus*	9	8
Need for alternative haemostatic therapy	3	3
Serious adverse events^, number of participants	8	7

*greater than the 2 allowed by the protocol in any 24‐hour period; ^as assessed by the investigators, including therapeutic failures.