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. 2024 Jul 12;29:103. doi: 10.1186/s11658-024-00616-3

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — The mechanism of eccDNA-derived FAM84B regulation of PCa progression. The eccDNA in PCa promotes the expression of FAM84B through the intact transcript it carries. FAM84B promotes the transcriptional activation of MYC on WWP1 by inducing MYC that is coterminous with the 8q24.21 gene desert in a beta catenin-dependent manner and mediates the degradation of CDKN1B by WWP1. The repression of MYC expression by CDKN1B was alleviated by negative feedback regulation, thereby accelerating PCa progression