| Methods |
Observational cohort study (embedded in a PMTCT cohort study) |
| Participants |
18 HIV‐infected children and 57 HIV‐uninfected children in Abidjan, Côte d'Ivoire |
| Interventions |
Between June 1991 and June 1993 all children received a single 0.5 ml dose of 17D YF vaccine and measles vaccine at a mean of 10 months of age (range 7 months to 14 months). Children were followed for a median 29 months. |
| Outcomes |
Adequate YF antibody response. |
| Notes |
Pre‐ART era |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
High risk |
Observational study |
| Allocation concealment (selection bias) |
High risk |
Observational study |
| Blinding of participants and personnel (performance bias)
All outcomes |
High risk |
Observational study |
| Blinding of outcome assessment (detection bias)
All outcomes |
High risk |
Observational study |
| Incomplete outcome data (attrition bias)
All outcomes |
High risk |
Adverse events were not systematically ascertained |
| Selective reporting (reporting bias) |
Unclear risk |
Insufficient information to permit judgment of 'Yes' or 'No'. |
| Other bias |
Unclear risk |
Study predates antiretroviral therapy. Patient immunologic and virologic markers not provided. |
