Table II.
Clinical characteristics of pregnancies with and without Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). National Inpatient Sample, Healthcare Cost and Utilization Project (HCUP), 2009-2020
| Characteristics | SJS/TEN pregnancy | Non-SJS/TEN pregnancy | P-value |
|---|---|---|---|
| Number of hospitalizations, N | 650 | 49,138,785 | |
| Length of stay, days, median (IQR) | 3 (2-5) | 2 (2-3) | <.001 |
| Mortality, N (%) | ≤10 | 8190 (0.2) | <.001 |
| Metabolic disorders | |||
| Diabetes, N (%) | 20 (3.1) | 634,837 (1.3) | .077 |
| Obesity, N (%) | 40 (6.2) | 2,971,577 (6.0) | .980 |
| Infections | |||
| Hepatitis B or C, N (%) | ≤10 | 277,686 (0.6) | .139 |
| HIV positive, N (%) | ≤10 | 32,454 (0.1) | .002 |
| Mycoplasma infection, N (%) | ≤10 | 2456 (<0.1) | <.001 |
| Herpes simplex virus infection, N (%) | 35 (5.4) | 1,055,407 (2.1) | .011 |
| Genitourinary tract infection, N (%) | 64 (9.8) | 1,106,462 (2.3) | <.001 |
| Other | |||
| Malignant neoplasm, N (%) | ≤10 | 36,030 (0.1) | .003 |
| Cutaneous autoimmune disease, N (%) | 54 (8.3) | 85,685 (0.2) | <.001 |
| Lupus, N (%) | 54 (8.3) | 82,917 (0.2) | <.001 |
| Intravenous drug use, N (%) | 15 (2.3) | 453,403 (0.9) | .098 |
| Pregnancy complications | |||
| Pre-eclampsia, N (%) | 45 (6.9) | 2,601,189 (5.3) | .403 |
| Fetal heart rate/rhythm abnormality, N (%) | 49 (7.5) | 7,144,329 (14.5) | .024 |
| Number of deliveries, N | 378 | 44,355,925 | |
| Length of stay, days, median (IQR) | 2 (2-3) | 2 (2-3) | .048 |
| Live birth, N (%) | 373 (98.7) | 44,027,841 | .555 |
| Still birth, N (%) | ≤10 | 345,179 (0.8) | .591 |
| Preterm birth, N (%) | 64 (16.9) | 3,636,024 (8.2) | .005 |
| Post-term birth, N (%) | 35 (9.3) | 5,583,620 (12.6) | .372 |
Statistically significant P-values (less than .05) are bolded.
HIV, Human immunodeficiency virus; IQR, interquartile range.