Table III.

Risk factors for the development of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in pregnant women. National Inpatient Sample, Healthcare Cost and Utilization Project (HCUP), (2009-2020)

Risk Factors		Crude odds ratio (95% CI)	Crude P-value	Adjusted odds ratio (95% CI)	Adjusted P-value
Demographics
Age	≥30 (vs < 30)	0.99 (0.70-1.41)	.973	0.96 (0.65-1.28)	.821
Race/Ethnicity	White (vs other)	1.31 (0.92-1.88)	.137	1.40 (0.97-2.01)	.071
Metabolic disorders
Diabetes	Yes (vs no)	2.39 (0.88-6.47)	.086	2.25 (0.82-6.16)	.114
Obesity	Yes (vs no)	1.01 (4.94-2.06)	.980	0.81 (0.37-1.78)	.597
Infections
Hepatitis B or C	Yes (vs no)	2.75 (0.68-11.11)	.156	1.84 (0.41-8.24)	.423
HIV Positive	Yes (vs no)	1.17 (1.64-8.40)	.014	9.49 (1.24-7.24)	.030
Herpes simplex virus infection	Yes (vs no)	2.60 (1.21-5.57)	.014	2.49 (1.15-5.41)	.021
Genitourinary tract infection	Yes (vs no)	4.75 (2.68-8.43)	<.001	3.80 (2.01-7.16)	<.001
Other
Malignant neoplasm	Yes (vs no)	10.57 (1.48-75.62)	.019	8.67 (1.22-61.39)	.031
Lupus	Yes (vs no)	53.85 (2.90-99.99)	<.001	41.94 (20.78-84.66)	<.001
Intravenous drug use	Yes (vs no)	2.54 (0.81-7.97)	.111	1.65 (0.48-5.69)	.429
Pregnancy complications
Pre-eclampsia	Yes (vs no)	1.33 (0.68-2.63)	.405	1.27 (0.63-2.55)	.502

Adjusted logistic regression model adjusted for all variables.

Statistically significant P-values (less than .05) are bolded.

CI, Confidence interval; HIV, human immunodeficiency virus.