Table 3.
Potential Relevance of Variables to Biomarkers, EndpointS, and Other Tools Categories
| BEST Categories∗ |
|||||||
|---|---|---|---|---|---|---|---|
| Diagnostic | Monitoring | Predictive | Prognostic | Pharmacodynamic/Response | Safety | Susceptibility/Risk | |
| 7-ketocholesterol | X | ||||||
| Ang2 | X | X | X | X | X | X | |
| ANGPTL4 | |||||||
| CCL2/MCP-1 | X | X | X | X | X | X | |
| CCN2/CTGF | X | ||||||
| CCR2/CCR5 | X | X | X | X | |||
| CRP | X | X | X | X | X | ||
| DLL4 | X | ||||||
| Epoxide hydrolase - soluble | X | X | X | X | X | ||
| Erythropoietin derivatives | X | ||||||
| Fenofibrate/lipid/PPARα | X | X | X | X | X | ||
| IL-1b | X | X | X | X | |||
| IL-6 | X | X | X | X | X | X | |
| IL-8 | X | ||||||
| Inflammation | X | X | X | X | X | X | |
| Kynurenic acid and Egln1 | X | X | |||||
| lLpid metabolism (retinal-specific effects of fatty acids oxidation products, cholesterol, ceramide, lipid independent effects of PPARα activation) | X | X | X | X | X | ||
| LRG1 | X | X | X | X | X | X | |
| MiR200 | X | X | X | X | |||
| Mitochondrial targeting (mitophagy) | X | X | X | X | X | ||
| Neuroprotection | X | X | X | X | X | X | |
| Norrin | X | X | X | ||||
| Notch-3 | X | ||||||
| Nutrients | X | X | X | X | |||
| Oxidized cholesterols | X | X | X | ||||
| Plasma kallikrein | X | X | X | X | X | ||
| PIGF | X | X | X | X | X | X | |
| Proinflammatory cytokines | X | X | X | X | X | X | |
| RPB3 | X | X | X | X | X | X | |
| Semaphorin 3A | X | X | X | X | X | ||
| sICAM1 | X | X | X | ||||
| sVCAM1 | X | X | X | ||||
| TNFα | X | X | X | X | X | ||
| VEGF-A | X | X | X | X | X | X | |
| VEGF-R2 | X | X | X | X | |||
| VE-PTP | X | X | X | X | X | X | |
Ang2 = angiopoietin 2; ANGPTL4 = angiopoietin like 4; BEST = Biomarkers, EndpointS, and other Tools; CCL2/MCP-1 = chemokine ligand 2/monocyte chemoattractant protein-1; CCN2/CTGF = cellular communication network factor 2/connective tissue growth factor; CCR2/CCR5 = chemokine receptor 2/chemokine receptor 5; CRP = C-reactive protein; DLL4 = notch ligand delta like ligand 4; Egln1 = Egl-9 family hypoxia-inducible factor 1; IL = interleukin; LRG1 = leucine rich alpha-2-glycoprotein 1; miR200 = microRNA-200; PIGF = phosphatidylinositol glycan anchor biosynthesis class F; PPARα = peroxisome proliferator-activated receptor alpha; RBP3 = retinol binding protein 3; sICAM1 = soluble intercellular adhesion molecule-1; sVCAM1 = soluble vascular cell adhesion molecule-1; TNFα = tumor necrosis factor alpha; VEGF-R2 = VEGF receptor 2; VE-PTP = vascular endothelial protein tyrosine phosphatase.
Summary of the value of each biomarker based on BEST analysis.
Definitions see FDA-NIH Biomarker Working Group.2