FIG. 1.

Amino acid sequence of murine nectin-1α in comparison with that of human nectin-1α. Predicted features of these proteins, which are 95% identical in amino acid sequence, include a signal sequence (dotted underline), a membrane-spanning domain (solid underline) and potential sites for addition of N-linked glycans (boxed residues). The solid diamonds mark the conserved cysteine residues, and the solid circles identify the sequence motif required for binding to the PDZ domain in afadin. The sequence presented here is for murine nectin-1α from FVB/N mice. Amino acid substitutions and a gap in sequence reported for nectin-1α from C3H mice (25) are shown above the FVB/N sequence. The sequence given for human nectin-1α is that reported by Geraghty et al. (13), which differs somewhat from that reported by Lopez et al. (22).