Rare HCV GT subtypes in DAA-naive vs. -experienced patients.
(A) Overall frequencies of rare GT subtypes in patients after first and second generation DAA failure compared to DAA-naive patients. (B) Distribution of rare HCV subtypes among DAA-failure patients, stratified for first and second generation DAAs. DAA, direct-acting antiviral; GT, genotype. Patients with rare GT6 subtypes and PrOD, GZR/EBR, LDV/SOF failure were partially misclassified as GT1 in commercial genotyping assays.