Table 2.

NS5A signature RASs detected in DAA-failure patients with rare GT.

Rare GT	Pos. 24	Pos. 28	Pos. 30	Pos. 31	Pos. 93
GT1c/e/l/∗	K24G/R	M28V (n = 1 pt.)	Q30R (n = 1 pt.)	L31M	Y93H (n = 1 pt.)
GT2k	No. pts. with NS5A inhibitor pretreatment
GT3b/g/h/i//∗	—	—	A30K	L31M	Y93H (n = 1 pt.)
GT4b/c/f/n/o/r/v∗	—	L28M/V	L30R	M31L	Y93H (single pts.)
GT5a	No RASs
GT6e/f/n/r	—	F28M (n = 1 pt.)	—	—	Y93S (n = 1 pt.)

DAA, direct-acting antiviral; GT, genotype; NS5A, non-structural protein 5A, pt., patient; RASs, resistance-associated substitutions.

^∗Subtype unassigned.