Table 3.

Published in vitro resistance levels of RASs in rare GT1, GT3, and GT4 subtypes.

Rare GT	Tested isolate	DCV EC50 fold change∗	VEL EC50 fold-change∗	PIB EC50 fold change∗	Reference
Subtype 1l	Q30R + L31M	∼3	∼2	∼30	Nguyen et al.
Subtype 4r	L28M + L30R + L31M	∼40	∼1	∼0.8	Nguyen et al.
Subtype 4r	L28M + L30R + Y93H	∼700	∼8	∼7	Nguyen et al.
Subtype 3b/3g†	A30K + L31M	∼10,000	∼40,000	∼60	Smith et al.
Subtype 3b/3g†	A30K + L31M + Y93H	∼40,000	∼40,000	∼60	Smith et al.

^∗Compared with wild-type replicon in vitro.

^†Substitutions tested in subtype 3a replicon. DCV, daclatasvir; GT, genotype; PIB, pibrentasvir; RASs, resistance-associated substitutions; VEL, velpatasvir.