Table 1.
Comparison of demographic, clinical, and radiographic parameters between the periprosthetic fracture cohort and the two control cohorts
| Parameters mean (± SD) | PPF n = 40 | AR n = 40 | OA n = 40 | p-value (PPF vs. AR) | p-value (PPF vs. OA) |
|---|---|---|---|---|---|
| Age (yr.) | 72.5 (± 11.1) | 72.5 (± 9.3) | 71.6 (± 10.3) | > 0.99 | 0.534 |
| Sex ratio (f/m) | 26/14 | 26/14 | 26/14 | > 0.99 | > 0.99 |
| BMI (kg/m2) | 26.4 (± 4.0) | 27.2 (± 4.5) | 27.1 (± 3.7) | 0.218 | 0.150 |
| Time in situ (yr.) | 6.6 (± 9.5) | 9.9 (± 9.9) | – | 0.005 | – |
| Lowest T-score | − 1.78 (± 1.78) | − 0.65 (± 1.58) | − 0.77 (± 1.34) | 0.001 | 0.005 |
| Lowest Z-score | − 0.62 (± 1.69) | 0.36 (± 1.52) | 0.36 (± 1.29) | 0.004 | 0.004 |
| Normal BMD (%) | 13/40 (32.5) | 26/40 (65) | 23/40 (57.5) | 0.007 | 0.040 |
| Osteopenia (%) | 9/40 (22.5) | 9/40 (22.5) | 13/40 (32.5) | > 0.99 | 0.450 |
| Osteoporosis (%) | 18/40 (45) | 5/40 (12.5) | 4/40 (10) | 0.003 | < 0.001 |
| Vitamin D (%) | 22/40 (55) | 15/40 (37.5) | 7/40 (17.5) | 0.180 | < 0.001 |
| BP/Dmab (%) | 9/40 (22.5) | 1/40 (2.5) | – | 0.010 | – |
Bold indicates significant differences
PPF periprosthetic fracture, AR aseptic revision, OA osteoarthritis, yr. years, f female, m male, BMI body mass index, BMD bone mineral density, BP bisphosphonates, Dmab denosumab