Fig. 3.

CD73 inhibitor AB680 synergizes with GC chemotherapy to inhibit CCLP1 tumor growth in vivo. (A) Establishment of the subcutaneous xenograft model with nude mice using sh-MOCK or CD73-knockdown CCLP1 cells. Growth curves (B), gross images (C), volumes and weight (D) of CCLP1 subcutaneous tumors from indicated groups. (E) Subcutaneous xenograft model with nude mice using vector or CD73-OE CCLP1 cells. Growth curves (F), gross images (G), volumes and weight (H) of CCLP1 subcutaneous tumors from indicated groups. (I) Subcutaneous CCLP1 tumor-bearing nude mice receiving PBS, Gem/Cis chemotherapy, CD73 inhibitor AB680, or combination therapy. Growth curves (J), gross images (K), volumes and weight (L) of CCLP1 tumors from indicated treatment groups. *P < 0.05, **P < 0.01, ***P < 0.001