Fig. 5.

Illustrative cases of two patients with unknown diagnosis: Patient_1 is 51 years old, and Patient_2 is 49 years old. The images display an extensive non-enhancing component beyond the enhancing tumor margins. This could be attributed to infiltrative tumor, edema, or a coexistence of both. rCBV color maps focused analysis allow the detection of small foci of slightly elevated rCBV (arrows) in the non-enhancing component of Patient_2, while it depicts clear areas of very low rCBV (arrows) in Patient_1. Quantification of the 30th percentile in non-enhancing areas indicates that Patient_1 has values that fall within the range of Glioblastoma (Gb), while Patient_2 aligns with Astrocytoma grade 4 (Astro 4). The diagnoses for both cases were histopathology confirmed