Figure 4.

Variant allele frequency changes. Data are represented as with median and interquartile range. (a) Comparison in the VAF sum of pathogenic alterations between those with disease control at first tumor assessment (white) and those without (black) in both baseline plasma sample and first tumor assessment plasma sample. (b) Comparison in the VAF sum of pathogenic alterations between baseline plasma sample and progression plasma sample. (c-e) Dynamics of the VAF in some subjects in which the same alteration was observed in baseline, first tumor assessment and progression plasma samples. All comparisons were performed by Mann-Whitney U test.