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. 2024 Jul 13;10:74. doi: 10.1038/s41540-024-00398-6

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Mutations are depicted with red “explosions” with their original module (condensation) numbers in brackets. Black arrows indicate communication between modules, red arrows indicate direct influence from mutations and dashed arrows indicate indirect communication. Modules are ranked in order, and curly brackets contain the original numeration from the condensation graph. Lastly, the PIK3 (P↓)/BAX (B↑) targets are shown in blue with respect to their location inside or outside modules to show their downstream modular effects. a–p Show each of the 16 mutation combinations and their respective modular influences.

Fig. 5 — Mutations are depicted with red “explosions” with their original module (condensation) numbers in brackets. Black arrows indicate communication between modules, red arrows indicate direct influence from mutations and dashed arrows indicate indirect communication. Modules are ranked in order, and curly brackets contain the original numeration from the condensation graph. Lastly, the PIK3 (P↓)/BAX (B↑) targets are shown in blue with respect to their location inside or outside modules to show their downstream modular effects. a–p Show each of the 16 mutation combinations and their respective modular influences.