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. 2024 Jul 13;14:16178. doi: 10.1038/s41598-024-67284-3

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Identifcation and analysis of hub genes. (A) Protein–protein interaction network from String10.0. The purpler the node represents its higher significance, the yellower it is the opposite. (B) Cluster 1 from MCODE analysis of key genes. (C) Cluster 2 from MCODE analysis of key genes. (D) Identifcation of hub genes by CytoHubba of MCC ranking method. (E) Identifcation of hub genes by CytoHubba of MNC ranking method. (F) Identifcation of hub genes by CytoHubba of Dgree ranking method. (G) Hub genes and their co-expression genes were analyzed by GeneMANIA.