. 2024 Jul 13;4:142. doi: 10.1038/s43856-024-00569-w

Table 2.

Incidence rate ratios from Poisson regression analysis, estimates represent the association between elevated levels of C-reactive protein (CRP) (≥4.73 μg/mL) and 6-year incident dementia in the United States Health and Retirement Study

	Incident Dementia
	Overall N = 6908		Minoritized (non-Hispanic Black & Hispanic) N = 1446		Non-Hispanic Black N = 813		Hispanic N = 633		Non-Hispanic white N = 5462
Models
Unadjusted	IRR^a	95% CI^a	IRR^a	95% CI^a	IRR^a	95% CI^a	IRR^a	95% CI^a	IRR^a	95% CI^a
<75^th	1	-	1	-	1	-	1	-	1	-
≥75^th (≥4.73 μg/mL)	1.13	[0.97,1.32]	1.11	[0.87,1.41]	0.83	[0.61,1.13]	1.67^**	[1.13,2.46]	1.00	[0.82,1.23]
Demographic^b
<75^th	1	-	1	-	1	-	1	-	1	-
≥75^th (≥4.73 μg/mL)	1.21^*	[1.04,1.41]	1.26	[0.99,1.60]	0.99	[0.72,1.34]	1.80^**	[1.23,2.65]	1.19	[0.98,1.45]
Risk Factors^c
<75^th	1	-	1	-	1	-	1	-	1	-
≥75^th (≥4.73 μg/mL)	1.25^**	[1.07,1.46]	1.27	[0.99,1.63]	0.99	[0.72,1.37]	1.89^**	[1.29,2.77]	1.23^*	[1.01,1.50]
Chronic Conditions^d
<75^th	1	-	1	-	1	-	1	-	1	-
≥75^th (≥4.73 μg/mL)	1.23^**	[1.05,1.44]	1.26	[0.98,1.62]	1.00	[0.72,1.37]	1.85^**	[1.27,2.70]	1.19	[0.98,1.45]

^aIRR: incidence rate ratio, CI: confidence interval in brackets,

^bDemographic model: adjusted for age, sex, education categories, APOE-ε4 allele status, and wave. Note: the demographic model in the overall sample (N = 6908) additionally adjust for racialized social groups

^cRisk factors model: adjusted for age, sex, education categories, APOE-ε4 allele status, wave, smoking status, alcohol consumption, body mass index.

^dChronic conditions model: adjusted for age, sex, education categories, APOE-ε4 allele status, wave, smoking status, alcohol consumption, body mass index, and chronic conditions

^*p < 0.05, ^**p < 0.01, ^***p < 0.001

Models are stratified by racialized social groups and minoritized status.