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. 2024 Jul 10;19:6945–6980. doi: 10.2147/IJN.S467876

Table 1.

The Examples of Albumin Nanoparticles Modified with Non-Targeted Modification Polymers

Polymer Mechanism NP Diameter Preparation Techniques of Nanoparticles Ref
PEG Coupled with the active amino group on the surface of albumin PEGylation of HSA-NPs 120~150 nm Desolvation [84]
PEG Coupled with the active amino group on the surface of albumin PEG conjugated onto the Cys-34 residue of HSA loaded with PTX PEG5k:105 nm
PEG20k: 141 nm
Self-assemble [85]
PEG Coupled with the active amino group on the surface of albumin Apatinib-loaded HSA-PEG5k Before and after lyophilization were 131.7 ± 3.5 and 169.6 ± 5.2 nm Emulsification [86]
PEG Coupled with the active amino group on the surface of albumin HSA-PEG5k-NP loaded with PTX 176 ± 3.6 nm Self-assemble [87]
Chitosan Electrostatic adsorption Chitosan -coated BSA-NPs loaded with Tetrandrine 237.9 ± 3.61nm Desolvation [88]
Chitosan Electrostatic adsorption Chitosan-BSA nanoparticles loaded with abaloparatide and acetylsalicylic acid 289 ± 34 nm Desolvation [89]
Chitosan Electrostatic adsorption Reduced bovine serum albumin and glycol chitosan nanoparticles loaded with PTX 349 ± 26 nm Self-assemble [90]
Chitosan Electrostatic adsorption Chitosan -coated-HSA loaded with gemcitabine 200 ± 4 nm Desolvation [91]
PEI Electrostatic adsorption BSA-PEI NPs for efficient delivery of CRISPR/Cas9 system 102.50 nm [92]
PEI Electrostatic adsorption PEI-HSA-NPs loaded with chlorhexidine 465.2 ± 11.3 nm Desolvation [93]
PEI Electrostatic adsorption BSA-PEI was utilized to modify gold nanospheres (AuNSs) and gold nanorods (AuNRs) 200 nm [94]
PEI Electrostatic adsorption ε-caprolactone modified polyethylenimine-OVA NPs Around 200 nm Self-assemble [95]
PEI Electrostatic adsorption pGL3 plasmid-PEI-coated HSA NPs 191 ± 4 nm Desolvation [96]
Polycation/polyanion deposition Albumin surface coating Poly(arginine) (pARG) and poly (ethylene glycol)-block-poly (L-aspartic acid)-based nab-PTX nanoparticles 100~140 nm Desolvation [97]
Polycation/polyanion deposition Albumin surface coating L-b-L by coating of the HSA-IFN-α NPs with poly(sodium-4-styrene) sulphonate and chitosan 10 ± 5 nm pH-condensation [98]
Polycation/polyanion deposition Albumin surface coating Dox-BSA-NPs with HA and Poly (L-lysine hydrobromide) by LBL 143 ± 3.79 nm Desolvation [99]

Note: -: no date.

Abbreviations: PEG, Polyethylene glycol; PEI, Polyethylenimine; HSA, human serum albumin; NPs, nanoparticles; BSA, bovine serum albumin; LBL, layer-by-layer; Dox, doxorubicin; PTX, Paclitaxel.